Monday, May 19, 2014

Hotspot Shield 3.32 Free Download



Description:

Hotspot Shield is a VPN application, developed by AnchorFree, which allows the viewing of websites that can’t be accessed from your geographical area due to restrictions. Additionally you can protect your Internet connection from snoopers that could spy on your traffic and avoiding monitoring processes thanks to the encryption it provides. In this way, besides providing safe access to worldwide information, it can unlock general services whilst keeping your computer protected against unwanted malware thanks to its impenetrable tunnel. This application is known for the security it grants along with the possibility of avoiding censorship. Using Hotspot Shield you can establish your connection as if you were in another country: for example, in the United States, Japan or Australia. In this way, you can access Internet services that are not currently available in your country, like videos that are geographically restricted due to copyright terms or any other kind of website, without risking the security of your computer during the process. It can unlock general services while your computer is protected against unwanted malware The application has been awarded with recognitions such as the Best Online Security/Privacy Application by 2013 Appy Awards for its contribution to users’ privacy. This security is granted via a 128-bit SSL encryption that lets its users surf the Internet anonymously through the author’s gateway. This process avoids data theft while you are using Hotspot Shield, assuring a safe connection without the need for difficult settings, as well as unlocking all kinds of webpages for you.


How to use

 Once you get the application on your computer, Hotspot Shield will work just fine without advanced configurations. The application will appear disconnected in the lower taskbar in Windows systems and in the taskbar above for Mac OS. Firstly, you just have to close your active browsers before you open the VPN application. Then, for getting the full protection of the software click on the connect button. The process takes a bit less than a minute to completely protect your Internet connection. Once you get connected, you can browse the websites you desire in the normal way, according to the country you have chosen from the available list. You may note that the Internet speed is a bit slower when you have activated the program, but it won’t be a great annoyance for average broadband Internet connections. In fact, the download speed reduction is a lot smaller than it would be thought to start with, but the ping increases several times depending on the destination chosen. Hotspot Shield doesn’t offer many advanced features, as it's a simple tool, and this could be a problem for advanced users that want a great variety of settings and possibilities. The great thing is that it does not require additional software to work, offering all the original functions that it promises from the moment you have the application installed on your computer.





Freemake Video Downloader




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Monday, September 24, 2012

Tramadol hydrochloride (Ultram, Tramal)



Tramadol

Tramadol hydrochloride (UltramTramal) is a centrally acting synthetic opioid analgesic used in treating moderate to moderately-severe pain. The drug has a wide range of applications, including treatment of rheumatoid arthritis, restless legs syndrome and fibromyalgia. It was developed by the pharmaceutical company Grünenthal GmbH in the late 1970s.


Tramadol is a weak Î¼-opioid receptor agonist, releases serotonin, and inhibits the reuptake of norepinephrine. While its analgesic action is thus rather distinct from opioids per se, tramadol is a synthetic analog of the phenanthrene alkaloid codeine. Tramadol is converted to O-desmethyltramadol, a significantly more potent μ-opioid agonist. The euphoria and respiratory depression of opioids are mainly caused by the μ1 and μ2 receptors; the addictive nature of tramadol, as well as other opioids, is due to these effects, but tramadol's serotonergic and noradrenergic effects may also contribute to possible dependence. The opioid agonistic effect of tramadol and its major metabolite(s) is almost exclusively mediated by μ-opioid receptors. This further distinguishes tramadol from opioids in general (including morphine), which do not possess tramadol's degree of subtype selectivity and are much stronger opiate-receptor agonists.


Medical uses


Tramadol is used similarly to codeine, to treat moderate to moderately severe pain. Pharmacologically, Tramadol is similar to levorphanol (albeit with much lower μ-agonism), as both agents are also NMDA-antagonists with SNRI activity. Dextropropoxyphene (Darvon) & M1-like molecule tapentadol (Nucynta, a new synthetic atypical opioid made to mimic the agonistic properties of tramadol's metabolite, M1(O-Desmethyltramadol)) also have similar activities. Tramadol is also molecularly similar to venlafaxine (Effexor) and has similar SNRI effects, with antinociceptive effects also observed. It has been suggested that tramadol could be effective for alleviating symptoms of depression, anxiety, and phobias because of its action on the noradrenergic and serotonergic systems, such as its "atypical" opioid activity. However, health professionals have not endorsed its use for these disorders, claiming it may be used as a unique treatment (only when other treatments failed), and must be used under the control of a psychiatrist
In May 2009, the United States Food and Drug Administration issued a Warning Letter to Johnson & Johnson, alleging that a promotional website commissioned by the manufacturer had "overstated the efficacy" of the drug, and "minimized the serious risks". The company which produced it, the German pharmaceutical company Grünenthal GmbH, were alleged to be guilty of "minimizing" the addictive nature and proposed efficacy of the drug, although it showed little abuse liability in preliminary tests. The 2010 Physicians Desk Reference contains several warnings from the manufacturer, which were not present in prior years. The warnings include more compelling language regarding the addictive potential of tramadol, the possibility of difficulty breathing while on the medication, a new list of more serious side effects, and a notice that tramadol is not to be used in place of opiate medications for addicts. Tramadol is also not to be used in efforts to wean addict patients from opiate drugs, nor to be used to manage long-term opiate addiction.

Availability and usage


Tramadol is classified as a central nervous system drug usually marketed as the hydrochloride salt (tramadol hydrochloride); the tartrate is seen on rare occasions, and rarely (in the US at least) tramadol is available for both injection (intravenous and/or intramuscular) and oral administration. The most well known dosing unit is the 50 mg generic tablet made by several manufacturers. It is also commonly available in conjunction with APAP (paracetamol, acetaminophen) as Ultracet, in the form of a smaller dose of 37.5 mg tramadol and 325 mg of APAP. The solutions suitable for injection are used in patient-controlled analgesia pumps under some circumstances, either as the sole agent or along with another agent such as morphine.
Tramadol comes in many forms, including:
  • capsules (regular and extended release)
  • tablets (regular, extended release, chewable, low-residue and/or uncoated tablets that can be taken by the sublingual and buccal routes)
  • suppositories
  • effervescent tablets and powders
  • ampules of sterile solution for SC, IM, and IV injection
  • preservative-free solutions for injection by the various spinal routes (epidural, intrathecal, caudal, and others)
  • powders for compounding
  • liquids both with and without alcohol for oral and sub-lingual administration, available in regular phials and bottles, dropper bottles, bottles with a pump similar to those used with liquid soap and phials with droppers built into the cap
  • tablets and capsules containing (acetaminophen/APAP), aspirin and other agents.  

Tramadol has been regularly used in the form of an ingredient in multi-agent topical gels, creams, and solutions for nerve pain, rectal foam, concentrated retention enema, and a skin plaster (transdermal patch) quite similar to those used with lidocaine.
Tramadol has a characteristic and unpleasant taste which is mildly bitter but much less so than morphine and codeine. Oral and sublingual drops and liquid preparations come with and without added flavoring. Also, 50 mg water-soluble tramadol tablets has strawberry-flavouring, no matter which company manufactured it, to distinguish every, same-looking and same sized Mirtazapine sublingual tablets, which has orange flavouring irrespective of the manufacturer. This different flavouring is considered to be a standard. Its relative effectiveness via transmucosal routes (i.e. sublingual, buccal, rectal) is similar to that of codeine, and, like codeine, it is also metabolized in the liver to stronger metabolites (see below).
The maximum dosage per day is 400 mg for oral use and 600 mg for parenteral use. Certain manufacturers or formulations have lower maximum doses. For example, Ultracet (37.5 mg/325 mg tramadol/APAP tablets) is capped at 8 tablets per day (300 mg/day) due to its acetaminophen content. Ultram ER is available in 100, 200, and 300 mg/day doses and is explicitly capped at 300 mg/day as well.
Patients taking SSRIs, SNRIs, TCAs, MAOIs, or other strong opioids (oxycodone, methadone, fentanyl, morphine), as well as the elderly, pediatric, and those with severely reduced renal or hepatic function should consult their doctor regarding adjusted dosing or whether to use tramadol at all.

What is Tramadol


Tramadol is a narcotic-like pain reliever.
Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.
Tramadol may also be used for other purposes not listed in this medication guide.

Important information about tramadol

You should not take this medication if you are allergic to tramadol, if you have ever been addicted to drugs or alcohol, or if you have ever attempted suicide. Do not take tramadol while you are intoxicated (drunk) or taking any of the following: alcohol or street drugs, narcotic pain medicine, sedatives or tranquilizers, or medicine for depression, anxiety, or mental illness.
Seizures (convulsions) have occurred in some people taking this medicine. Tramadol may be more likely to cause a seizure if you have a history of seizures or head injury, a metabolic disorder, or if you are taking certain medicines such as antidepressants, muscle relaxers, narcotic, or medicine for nausea and vomiting.
Seek emergency medical attention if you think you have used too much of this medicine. A tramadol overdose can be fatal.
Tramadol may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.
Do not crush the tramadol tablet. This medicine is for oral (by mouth) use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death.

Before taking tramadol
You should not take this medication if you are allergic to tramadol, if you have ever been addicted to drugs or alcohol, or if you have ever attempted suicide.
Do not take tramadol while you are intoxicated (drunk) or taking any of the following:
  • alcohol or street drugs;
  • narcotic pain medicine;
  • sedatives or tranquilizers (such as Valium);
  • medicine for depression or anxiety; or
  • medicine for mental illness (such as bipolar disorder, schizophrenia).
Seizures have occurred in some people taking tramadol. Talk with your doctor about your seizure risk, which may be higher if you have:
  • a history of drug or alcohol addiction;
  • a history of epilepsy or other seizure disorder;
  • a history of head injury;
  • a metabolic disorder; or
  • if you are also taking an antidepressant, muscle relaxer, narcotic, antipsychotic, or medicine for nausea and vomiting.
To make sure you can safely take tramadol, tell your doctor if you have any of these other conditions:
  • kidney disease (or if you are on dialysis);
  • cirrhosis or other liver disease;
  • a stomach disorder; or
  • a history of depression, mental illness, or thoughts of suicide.
Tramadol may be habit forming and should be used only by the person it was prescribed for. Never share tramadol with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.
FDA pregnancy category C. It is not known whether tramadol will harm an unborn baby. Tramadol may cause serious or fatal side effects in a newborn if the mother uses this medication during pregnancy or labor. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Tramadol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking tramadol. Do not give this medication to anyone younger than 16 years old without the advice of a doctor.


Thursday, August 23, 2012

Download CorelDRAW Graphics Suite X6 Fullversion

CorelDRAW Graphics Suite X6, Whether you’re an aspiring artist or an experienced designer, CorelDRAW® Graphics Suite X6 is your trusted graphic design software solution. With its content-rich environment and professional graphic design, photo-editing and website design software, you have everything you need to express your style and creativity with endless possibilities





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